Assessment of vascular form and function in Diabetes Mellitus by Non Invasive Vascular tools

Assessment of vascular form and function in Diabetes Mellitus by Non Invasive Vascular tools - Vascular form and function in Diabetes Mellitus

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32397

Enrollment

500

Registered

2008-11-25

Start date

2008-11-25

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes diabetes mellitus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with diabetes mellitus (patients with type 2 diabetes mellitus or patients with a minimum duration of 5 years with type 1 diabetes mellitus). Patients in the age range 20-75 years.

Exclusion criteria

Exclusion criteria: Patients with known extensive cardiovascular disease Patients with recent history of malignancy Patients who have recently undergone an operation Patients with or with recent infection or inflammation

Design outcomes

Primary

Measure	Time frame
Vascular form and function in patients with diabetes mellitus: Carotid intima media thickness (CIMT), assessment of vascular stiffness by pulse wave velocity (PWV), assessment of endothelial function by flow mediated dilation (FMD), assessment of capillary density and structure by orthogonal polarization spectral (OPS). Correlation of the results of the non invasive vascular tools explained above with diagnosed cardiovascular pathology. Additional value of non invasive vascular tools in risk straitification and in identification of diabetic patients at higher risk for CVD. Density and structure of capillaries in patients with diabetes mellitus. Correlation of capillary density and structure with organic microvascular disease (eg myocardial ischemia, retinopathy) in patients with diabetes mellitus.	—

Measure

Time frame

Vascular form and function in patients with diabetes mellitus: Carotid intima media thickness (CIMT), assessment of vascular stiffness by pulse wave velocity (PWV), assessment of endothelial function by flow mediated dilation (FMD), assessment of capillary density and structure by orthogonal polarization spectral (OPS). Correlation of the results of the non invasive vascular tools explained above with diagnosed cardiovascular pathology. Additional value of non invasive vascular tools in risk straitification and in identification of diabetic patients at higher risk for CVD. Density and structure of capillaries in patients with diabetes mellitus. Correlation of capillary density and structure with organic microvascular disease (eg myocardial ischemia, retinopathy) in patients with diabetes mellitus.

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Countries

Netherlands

Outcome results