Release of endogenous ligands of Toll-like receptors type 4 during mechanical ventilation in surgical patients with healthy lungs

Release of endogenous ligands of Toll-like receptors type 4 during mechanical ventilation in surgical patients with healthy lungs - Release of endogenous ligands for TLR4 during mechanical ventilation.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32393

Enrollment

Registered

2008-05-20

Start date

2008-02-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventilator-induced lung injury

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Between 18-65 years old, American Society of Anesthesiologists (ASA) status 1 or 2, ability to speak Dutch, no (N)SAID intake within 36 hours prior to surgery, no history of drug dependency or abus, body weight between 60-100 kg with a BMI

Exclusion criteria

Exclusion criteria: Patients with pulmonary, cardiac, hepatic or renal disease or significant or instable disease of the central nervous system, patients that smoke, use of (N)SAIDs within 36 hours prior to surgery, history of drug dependence or drug abuse, BMI > 30 kg/m2 or

Design outcomes

Primary

Measure	Time frame
The studied variable is the IL-8 concentration of the HEK293-TLR4 reporter assay after exposure to bronchotracheal aspirate.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results