In vitro activation of monocytes from pregnant women by different types of bacterial lipopolysaccharides leads different immunological pathways

In vitro activation of monocytes from pregnant women by different types of bacterial lipopolysaccharides leads different immunological pathways - Changed immunological response to oral micro-organisms during pregnancy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32389

Enrollment

Registered

2008-12-11

Start date

2008-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immune response during pregnancy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age

Exclusion criteria

Exclusion criteria: Multiple pregnancy Growth restriction of the fetus Hypertension Chronical diseases Age > 40 years Smoking Influenza or fever within two weeks prior to bloodsampling Severe periodontal disease Presence of P. gingivalis

Design outcomes

Primary

Measure	Time frame
Expression of toll-like receptors on monocytes during pregnancy. Cytokine production of monocytes during pregnancy after stimulation with sonicates from different oral pathogenic micro-organisms and LPS of E. coli and P. gingivalis.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results