Variation of non-cholesterol sterol levels in a population of mildly hypercholesterolaemic subjects

Variation of non-cholesterol sterol levels in a population of mildly hypercholesterolaemic subjects - 'DAHLIA-1

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32378

Enrollment

160

Registered

2008-01-14

Start date

2007-12-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild hypercholesterolaemia slightly elevated cholesterol

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy male and female subjects, aged 18-65 years old, with an LDL-cholesterol concentration between 3.0-5.0 mmol/L.

Exclusion criteria

Exclusion criteria: Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or a history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident, will be excluded.

Design outcomes

Primary

Measure	Time frame
The variation in non-cholesterol sterol levels in 160 mildly hypercholesterolaemic subjects.	—

Secondary

Measure	Time frame
The differences in genetic polymorphisms in genes coding for NPC1L1 and ABCG5 and ABCG8 proteins between subjects with high and low non-cholesterol sterol levels.	—

Countries

Netherlands

Outcome results