Anorexia Anorexia Nervosa
Conditions
Interventions
During MRI scanning, participants drink 200 ml glucose solution through a
plastic tube.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: Female Anorexia nervosa diagnosed according to DSM-IV criteria. BMI 17.5 kg/m2 or less Age 18 - 30 years;Healthy controls: Female 18.5 kg/m2
Exclusion criteria
Exclusion criteria: Connected with anorexia nervosa - Physical condition such that participating in this study is not recommended (as judged by the treating physician of Centrum Eetstoornissen Ursula).;Other - Any genetic or somatic disease (e.g. fragile X syndrome,) affecting the brain - Diabetes mellitus or history of diabetes mellitus in first grade relatives - Any significant chronic disease - Any substance abuse or addiction according to DSM-IV criteria (except smoking).;Contra-indication to MRI scanning: - Claustrophobia - Pacemakers and defibrillators - Nerve stimulators - Intracranial clips - Intraorbital or intraocular metallic fragments - Cochlear implants - Ferromagnetic implants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in reaction pattern of neuronal activity (as measured with fMRI) in the hypothalamus in respons to intake of glucose in patients with anorexia nervosa as compared to healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed