MRI molecular imaging of (inflammatory) macrophages as a predictor of abdominal aortic aneurysm progression

MRI molecular imaging of (inflammatory) macrophages as a predictor of abdominal aortic aneurysm progression - Imaging of inflammation in AAA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32371

Enrollment

Registered

2008-07-23

Start date

2009-04-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AAA Aneurysm

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For phase 1: all patients with an AAA which are eligable for surgical repair. For phase 2: all patients with an AAA with a diameter between 30 and 50 mm which are under surveillance at our hospital.

Exclusion criteria

Exclusion criteria: Patients with clinical inflammatory AAA and/or other inflammatory disorders. Patients with contraindications for MR scanning, including a pacemaker, metal objects in the eye, middle ear implants, implanted pumps or neurostimulators. And relative contraindications for MR scanning: metal cardiac valve, intracranial clips/coils for aneurysm, vena cava filter and metal prosthesis. Patients with contraindication for contrast enhanced CT, including those with a previous anaphylactic response to the contrast medium and patients with diminished kidney function as reflected by a serum creatinine of >130 µmol/l.

Design outcomes

Secondary

Measure	Time frame
Secondary objectives are to associate the degree and distribution of the inflammation of the abdominal aortic wall of patients with AAA with (i) systemic markers of inflammation, and (ii) the distribution of the wall stress.	—

Primary

Measure	Time frame
The main study parameter is the change in relative decrease of the post USPIO MR signal between different follow up moments. This relative signal loss will be related to the maximal aortic diameter change between different follow up moments. The main objective of our study is to differentiate between patients with stable or slowly growing AAA from patients with rapidly growing AAA. We believe that inflammation is a major player in the process of growth. In order to achieve our main objective we need to relate the individual degree and distribution of the inflammation of the AAA wall to specific growth rate and patterns. Inflammation will be visualized by means of USPIO-enhanced MR.	—

Measure

Time frame

The main study parameter is the change in relative decrease of the post USPIO MR signal between different follow up moments. This relative signal loss will be related to the maximal aortic diameter change between different follow up moments. The main objective of our study is to differentiate between patients with stable or slowly growing AAA from patients with rapidly growing AAA. We believe that inflammation is a major player in the process of growth. In order to achieve our main objective we need to relate the individual degree and distribution of the inflammation of the AAA wall to specific growth rate and patterns. Inflammation will be visualized by means of USPIO-enhanced MR.

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Countries

Netherlands

Outcome results