Identification of the Pathophysiological Substrate of Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Identification of the Pathophysiological Substrate of Atrial Fibrillation in Patients Undergoing Cardiac Surgery - The pathophysiological substrate of atrial fibrillation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32366

Enrollment

Registered

2008-12-04

Start date

2009-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation heart rhythm disturbances

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with atrial fibrillation selected to undergo surgical treatment of AF alone or in combination with valvular and/or coronairy surgery. History of AF (both paroxysmal and chronic AF) Age between 18 and 80 years Patient did give informed consent in writing

Exclusion criteria

Exclusion criteria: Previous thoracic surgery (epicardial measurements not possible due to adhesions)

Design outcomes

Primary

Measure	Time frame
Sinus rhythm 6 and 12 month after treatment. Mortality (in hospital, 6 month and 12 month). Degree of fibrosis from the left atrial appendage. Atrial fibrillation cycle length from different atrial locations. Degree of electrogram fragmentation during AF from different locations of the right and left atria and the pulmonary veins. Conduction characteristics from different locations of the right and left atria and the pulmonary veins. Electrophysiological exit and entrance block after pulmonary vein ablation.	—

Measure

Time frame

Sinus rhythm 6 and 12 month after treatment. Mortality (in hospital, 6 month and 12 month). Degree of fibrosis from the left atrial appendage. Atrial fibrillation cycle length from different atrial locations. Degree of electrogram fragmentation during AF from different locations of the right and left atria and the pulmonary veins. Conduction characteristics from different locations of the right and left atria and the pulmonary veins. Electrophysiological exit and entrance block after pulmonary vein ablation.

—

Secondary

Measure	Time frame
Morbidity including CVA, TIA Hospital length of stay Use of antiarrhythmic agents Preoperative duration of AF. Preoperative echocardiographic parameters such as atrial dimensions, left ventricular dimensions and ejection fraction, valvular characteristics.	—

Countries

Netherlands

Outcome results