middle ear infection otitis media
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: I. - Patients 0-5yrs old, seen at the Out Patient Department of ENT-surgery by an ENT-specialist in the UMC St Radboud or Canius Wilhelmina Hospital with... - Episodes of recurrent Acute Otitis Media (rAOM) OR Chronic Otitis Media with Effusion (COME) OR Chronic Suppurative Otitis Media (CSOM) AND - Who will receive tympanostomy tubes. II. - Patients 0-16 yrs of age, seen at the Out Patient Department of ENT-surgery by an ENT-specialist in the UMC St Radboud or the Canisius Wilhelmina Hospital with... - Episodes of recurrent Acute Otitis Media (rAOM) OR Chronic Otitis Media with Effusion (COME) OR Chronic Suppurative Otitis Media (CSOM) AND... - who will undergo middle ear clean up surgery.
Exclusion criteria
Exclusion criteria: - no informed consent - age category other than 0-5 years - malignancies, organ transplantation in history, recent ear surgery e.g. mastoidectomy or cochlear implant (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PROPOSAL PART I - TYMPANOSTOMY TUBE INSERTION Determination of molecular and cellular immune response in relation to the viral and bacterial pathogens causing otitis media. PROPOSAL PART II - BIOFILM FORMATION Gene expression profiling of the three major bacterial pathogens: S. pneumoniae, H. influenzae and M. catarrhalis present in biofilm, in comparison to in vitro cultures or middle ear fluid. | — |
Secondary
| Measure | Time frame |
|---|---|
| PROPOSAL PART I - TYMPANOSTOMY TUBE INSERTION Otitis Media Demography. Viral and Bacterial Pathogen detection. Gene expression profiling of the three major bacterial pathogens: S. pneumoniae, H. influenzae and M. catarrhalis. PROPOSAL PART II - BIOFILM FORMATION Otitis Media Demography. Viral and Bacterial Pathogen detection. | — |
Countries
Netherlands
Outcome results
None listed