Deep brain stimulation for Parkinson's Disease: a feasibility study on anatomical, functional and diffusion-weighted MRI

Deep brain stimulation for Parkinson's Disease: a feasibility study on anatomical, functional and diffusion-weighted MRI - MRI for deep brain stimulation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32349

Enrollment

Registered

2008-07-11

Start date

2008-09-16

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: older than 18 years no known neurological deficits

Exclusion criteria

Exclusion criteria: subject displays abnormalities (anatomically or due to artifacts) on MRI scan metallic prosthesis, neurostimulator or pacemaker in subject's body other contra indications for MRI

Design outcomes

Primary

Measure	Time frame
The primary study parameters of this study are qualitative: the visibility of the STN on anatomical MRI, the visibility of fiber bundles and thus the STN connectivity as can be derived from diffusion-weighted MRI. Quantitative measures are the MRI image quality, represented as signal-to-noise ratio and contrast-to-noise ratio of the STN. We can analyze the spatial and angular resolution of the diffusion-weighted data. Concerning the functional MRI, the activation in the STN and other brain areas can be quantified using SPM2 software.	—

Measure

Time frame

The primary study parameters of this study are qualitative: the visibility of the STN on anatomical MRI, the visibility of fiber bundles and thus the STN connectivity as can be derived from diffusion-weighted MRI. Quantitative measures are the MRI image quality, represented as signal-to-noise ratio and contrast-to-noise ratio of the STN. We can analyze the spatial and angular resolution of the diffusion-weighted data. Concerning the functional MRI, the activation in the STN and other brain areas can be quantified using SPM2 software.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results