Immune regulation in Common Variable Immunodeficiency: the role of apoptosis and regulatory T cells.

Immune regulation in Common Variable Immunodeficiency: the role of apoptosis and regulatory T cells. - Immune regulation in CVID

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32339

Enrollment

Registered

2008-09-23

Start date

2009-07-31

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

defective antibody production of unknown cause primary immunodeficiency

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Diagnosis of CVID; based on recurrent respiratory tract infections, decreased total serum IgG (

Exclusion criteria

Exclusion criteria: Both patients groups: uncertainty about the diagnosis. Acute and/or severe infections at the moment of inclusion. XLA patients: existence of auto immune symptoms

Design outcomes

Primary

Measure	Time frame
1. Quantification and characterisation of apoptosis in T and B cells 2. Quantification and functional determination of regulatory T cells 3. Function of the thymus	—

Secondary

Measure	Time frame
1. The differences in the 3 abovementioned outcome parameters between healthy controls, CVID patients and XLA control patients for both the pediatric and adult population. 2. The differences in the 3 abovementioned outcome parameters between subgroups of CVID patients, namely patients with and without auto immune symptoms, also within the pediatric and adult population. 3. Correlation between the function of the thymus and the amount of regulatory T cells. 4. Correlation between regulatory T cells and apoptosis.	—

Measure

Time frame

1. The differences in the 3 abovementioned outcome parameters between healthy controls, CVID patients and XLA control patients for both the pediatric and adult population. 2. The differences in the 3 abovementioned outcome parameters between subgroups of CVID patients, namely patients with and without auto immune symptoms, also within the pediatric and adult population. 3. Correlation between the function of the thymus and the amount of regulatory T cells. 4. Correlation between regulatory T cells and apoptosis.

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Countries

Netherlands

Outcome results