Improving the accuracy of determination of onset of neuromuscular block

Improving the accuracy of determination of onset of neuromuscular block - A closer look at onset of neuromuscular block

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32338

Enrollment

Registered

2008-12-11

Start date

2009-04-07

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

muscle disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • General anaesthesia for two hours or more • ASA class I or II • Administration of rocuronium for intubation only • Administration of propofol for anaesthesia induction and maintenance • Operation allows neuromuscular monitoring using the TOF-Watch at the adductor pollicis muscle • Age 18-70 years • BMI

Exclusion criteria

Exclusion criteria: • Administration of drugs interfering with neuromuscular block or monitoring • Neuromuscular disease • Diabetes mellitus type I or II • Allergy to rocuronium • Allergy to propofol • Conditions interfering with neuromuscular monitoring using the TOF-Watch

Design outcomes

Primary

Measure	Time frame
The main study parameters are the prediction accuracy of a PK-PD-potentiation model fitted with a Bayesian procedure to the twitch response data gathered at the adductor pollicis (thumb) from 1 Hz ST neuromuscular stimulation. Bayesian prior values for PK model parameters will be obtained from relevant literature.	—

Secondary

Measure	Time frame
The secondary study parameters are the onset profile of (modeled) neuromuscular block predicted by the fitted PK-PD-potentiation model.	—

Countries

Netherlands

Outcome results