Narrow Band Imaging, Autofluorescence imaging, Chromoendoscopy or Confocal Endomicroscopy for the differentiation of adenomas and non-neoplastic polyps?

Narrow Band Imaging, Autofluorescence imaging, Chromoendoscopy or Confocal Endomicroscopy for the differentiation of adenomas and non-neoplastic polyps? - Advanced colonic imaging techniques for polyp differentiation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32325

Enrollment

Registered

2008-03-03

Start date

2008-02-14

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal adenomas colorectal polyps

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) previous (serrated) adenoma(s) on colonoscopy 2) previous colon carcinoma 3) hereditary non-polyposis colorectal cancer 4) positive family history for CRC 5) known present (serrated) adenoma(s) or colorectal cancer.

Exclusion criteria

Exclusion criteria: 1) allergy to fluorescein 2) pregnancy 3) beta-blocker use 4) non-correctable coagulopathy precluding biopsies 5) age * 18 years 6) inability to give informed consent

Design outcomes

Primary

Measure	Time frame
(1) Feasibility of confocal endomicroscopy (i.e. accuracy and percentage of confocal images with insufficient image quality).	—

Secondary

Measure	Time frame
(2) Comparison of accuracies of CE, NBI, AFI and confocal endomicroscopy for the endoscopic differentiation of detected lesions. (3) Comparison of interobserver agreement on endoscopic diagnosis by CE, NBI, AFI and confocal endomicroscopy.	—

Countries

Netherlands

Outcome results