Exercise induced airway obstruction Exercise induced asthma
Conditions
Interventions
2 exercise provocation tests.
Sponsors
Medisch Spectrum Twente
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (asthmatic subjects) - Clinical history of allergic rhinitis and/or allergic asthma. - Age between 12 and 17 years. - Ability to perform reproducible lung function tests, i.e. coefficient of the predicted value variation in 3 of 5 consecutive measurements
Exclusion criteria
Exclusion criteria: Exclusion criteria (asthmatic subjects) - Use of intranasal or systemic corticosteroids in the last 4 weeks prior to the study. - Use of antihistamines, cromoglycates, anticholinergics in two weeks prior to the study. - Use of long acting bronchodilators 24 hours before testing. - Use of short acting bronchodilators 8 hours before testing. - Other pulmonary or cardiac disorder. - Deviation of the FEV1 of more than 12 % from baseline spirometry and the FEV1 before subsequent exercise provocation challenges. - Signs of gastro-esophageal reflux. ;Exclusion criteria (healthy subjects) - Reported Illness in the past. - Exhaled NO of more than 20 ppb - Signs of gastro-esophageal reflux.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study endpoint will be the end of the exercise provocation test, where change in MIF50 will be linked to change in EELV. | — |
Countries
Netherlands
Outcome results
None listed