Allergic contact dermatitis to fragrances
Conditions
Interventions
All participants are offered patch tests, a skin irritability test and a
repeated open application test (user test) with (components of) cosmetics.
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Diagnosed contact allergy to fragrance (mix I and/or II) with a positive patch test (+, ++ or +++ interpreted according to the ICDRG guidelines) Clinical healthy skin of the back in two preceding weeks Written informed consent
Exclusion criteria
Exclusion criteria: Pregnancy or lactation Age under 18 or above 70 Legally incompetent adults Topical treatment of immunosuppressives on the back and arms within 7 days before performing patch tests and until finalization Commercial skin lotions and ointments on the back and arms less than 8 hours before patch testing Extensive UV exposure of the back and arms in the last 14 days before performing patch tests and until finalization Usage of systemic immunosuppressive drugs (e.g. prednison, acitretine, adalimumab, efalizumab, etanercept, methoxsaleen, cyclosporine, azathioprine, infliximab and methothrexate) NB: Medication that reasonably not intervenes with the study procedures (e.g. an antihistaminicum can be used during the study) Severe illness, defined as life threatening or severely disabling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameters are reactions regarding the ICDRG guidelines on patchtests, skin irritability tests and a repeated open application test (user test). | — |
Secondary
| Measure | Time frame |
|---|---|
| not applicable. | — |
Countries
Netherlands
Outcome results
None listed