Duchenne Muscular Dystrophy (DMD) muscular dystrophy
Conditions
Interventions
The intervention of study 1 will consist of a low-to-moderate intensity dynamic
exercise training. Boys will train their legs and arms with active-passive
cycling equipment. The intervention of stud
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Study 1 'Dynamic leg and arm exercise training for ambulant or recently wheelchair confined boys with DMD': - Boys with a DNA established diagnosis of Duchenne Muscular Dystrophy - Boys who are at the end of their ambulation phase and experience difficulty in at least one of the following activities: walking at normal speed, climbing stairs at normal speed, raising from the floor - Boys who are recently wheelchair confined (1-2 years after stop walking) and are able to stand (un)supported (eventually help needed), are able to touch the top of their head with both hands without assistance ;Study 2 'Functional training with arm support for boys with DMD who have been wheelchair confined for several years' - Boys with a DNA established diagnosis of Duchenne Muscular Dystrophy - Boys who are a few years wheelchair confined (2-5 years after stop walking) - Boys who have problems with lifting their arms and reaching, and are unable to touch the top of their head, are able to use their hands for daily activities and experience difficulties in lifting their arms and reaching
Exclusion criteria
Exclusion criteria: Study 1'Dynamic leg and arm exercise training for ambulant or recently wheelchair confined boys with DMD': - Other disabling diseases influencing mobility - Boys with a clinical symptomatic cardiomyopathy - Boys who are wheelchair confined and/or: are unable to stand and/or are unable to touch the top of their head with both hands - Boys 20 years old - Boys who already use an arm support
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcomes for study 1 will be muscle endurance and functional abilities of the lower and upper extremities, as assessed with bicycle ergometry and the Motor Function Measure (MFM). The primary outcome for study 2 will be functional abilities of the upper extremity (reaching, lifting, manipulating), as assessed with the Action Research Arm Test (ARAT). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes for both studies will be at the level of body functions and structures (e.g. muscle tissue), activities (e.g. activities in daily life) and participation (e.g. health related quality of life). | — |
Countries
Netherlands
Outcome results
None listed