Stress and Oesophageal Acid Perception

Stress and Oesophageal Acid Perception - Stress and Oesophageal Acid Perception

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32280

Enrollment

Registered

2007-12-18

Start date

2008-02-05

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gasto-oesophageal reflux disease heartburn

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers: no symptoms/history of gastro-oesophageal reflux disease Patients with gastro-oesophageal reflux disease: previously diagnosed with gastro-oesophageal reflux disease with good association between symptoms and reflux episodes

Exclusion criteria

Exclusion criteria: Surgery of the gastro-intestinal tract Psychiatric disorders

Design outcomes

Primary

Measure	Time frame
For both measurements time necessary to provoke first perception, discomfort and pain during the acid perfusion will be assessed.	—

Secondary

Measure	Time frame
Systolic and diastolic blood pressure (mmHg) and heart rate (beats/min) will be assessed during both measurements in order to assess the reaction to mental stress task. The State and Trait Anxiety Inventory (STAI)/Zelf Beoordelings Vragenlijst (ZBV) is scored before introducing the manometry and pH catheter on both measurement days. The pH recording will show pH levels in the distal oesophagus during the acid perfusion test continuously. Afterwards, total time with pH	—

Measure

Time frame

Systolic and diastolic blood pressure (mmHg) and heart rate (beats/min) will be assessed during both measurements in order to assess the reaction to mental stress task. The State and Trait Anxiety Inventory (STAI)/Zelf Beoordelings Vragenlijst (ZBV) is scored before introducing the manometry and pH catheter on both measurement days. The pH recording will show pH levels in the distal oesophagus during the acid perfusion test continuously. Afterwards, total time with pH

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Countries

Netherlands

Outcome results