Differences in tissue and plasma PYY and GLP-1 in lean and obese human subjects

Differences in tissue and plasma PYY and GLP-1 in lean and obese human subjects - Differences in PYY and GLP-1 in obese versus lean

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32276

Enrollment

Registered

2008-09-30

Start date

2008-10-01

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesitas obesity satiety

Interventions

1) extra biopsies during colonoscopy (planned on medical grounds) 2) meal test: blood sampling 5x, every 30 min.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy obese and lean subjects having a colonoscopy

Exclusion criteria

Exclusion criteria: Gastro-intestinal diseases or surgery which may affect transit time and absorption.

Design outcomes

Primary

Measure	Time frame
In obese subjects, tissue PYY and GLP-1 will be increased, whereas postprandial plasma PYY and GLP-1 secretion will be decreased, pointing to an L-cellular hyposecretion in obesity.	—

Secondary

Measure	Time frame
see primary parameters	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)