Role of connective tissue growth factor in peritoneal fibrosis and encapsulating peritoneal sclerosis

Role of connective tissue growth factor in peritoneal fibrosis and encapsulating peritoneal sclerosis - CTGF in peritoneal fibrosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32262

Enrollment

Registered

2008-09-02

Start date

2008-10-26

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

encapsulating peritoneal sclerosis peritoneal fibrosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with ESRD who are about to undergo a kidney transplantation in the University Medical Centre Utrecht.

Exclusion criteria

Exclusion criteria: Patients who are unable to give informed consent.

Design outcomes

Primary

Measure	Time frame
The main study parameters are thickness of the peritoneal submesothelial compact zone, CTGF mRNA and protein expression in the peritoneum, and CTGF levels in plasma, urine, and peritoneal effluent.	—

Secondary

Measure	Time frame
The secondary study parameters are the degree of vasculopathy in the peritoneum, TGF-β1 and VEGF mRNA and protein expression in the peritoneum, and TGF-β1 and VEGF levels in plasma, urine, and peritoneal effluent.	—

Countries

Netherlands

Outcome results