HNPCC Lynch syndrome
Conditions
Interventions
Patients will be randomised between conventional colonoscopy and
chromoendoscopy at baseline, followed by chromoendoscopy in all patients at two
year follow-up.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Proven or obligate (carrier state based on the position in the pedigree) mutation carriers, with a known mutation in the hMLH1, hMSH2 or hMSH6 gene, - who have their entire proximal colon in situ and - are aged between 20 and 70 years and - if written informed consent is provided.
Exclusion criteria
Exclusion criteria: Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints of the study are the number of adenomas, advanced adenomas, carcinomas at baseline and the number of the number of adenomas, advanced adenomas, carcinomas and the number of patients requiring colectomy at 2-year follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secundary endpoints of the study are the number of complications from colonoscopy at baseline and at 2-year follow-up. | — |
Countries
Netherlands
Outcome results
None listed