geen aandoening nvt
Conditions
Interventions
Participants will be treated with vardenafil 10 mg, vardenafil 20 mg, or a
placebo. All treatments will be taken orally. The treatment order will be
established by counterbalancing.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or female, 18 to 35 years of age, Healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected), Body mass index between 18.5 and 30, Willingness to sign an informed consent, Positive evaluation on the screening
Exclusion criteria
Exclusion criteria: A history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness. Other exclusion criteria are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the behavioural score on the memory tests; the verbal learning task (VLT), the object relocation task (ORT) and the continuous recognition memory task (CRMT),. Secondary, the event-related potentials during those tasks will be analysed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other important measures are the Tower of London (TOL) and the Stroop task. In addition, the visual and auditory evoked potentials (respectively VEPs and AEPs), which will give an indication of the role of vardenafil in information processing are important measures as well. Finally, the ratio (S2/S1) of the P50 is a measure of sensory gating. | — |
Countries
Netherlands
Outcome results
None listed