Evaluation of the predictive value of Dynamic MRI in determining treatment response in perianal fistulizing Crohn*s disease before and after treatment with Infliximab

Evaluation of the predictive value of Dynamic MRI in determining treatment response in perianal fistulizing Crohn*s disease before and after treatment with Infliximab - DCE-MRI in predicting treatment response perianal fistulizing CD.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32206

Enrollment

Registered

2008-05-20

Start date

2008-06-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn inflammatory bowel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: proven Crohn*s disease by endoscopy and/or histopathology draining perianal fistula

Exclusion criteria

Exclusion criteria: under 18 years of age general contraindications to MRI (claustrophobia, pregnancy, renal insufficiency, pacemakers).

Design outcomes

Primary

Measure	Time frame
Predictive value of DCE-MRI before anti-TNF treatment and during treatment (6 weeks) in predicting or identifying early response as compared to the PDAI after 6 weeks and 12 weeks. Predictive value of DCE-MRI after twelve weeks of anti-TNF treatment as compared to the PDAI after 1 year.	—

Secondary

Measure	Time frame
DCE-MRI compared to the MRI-based score, CRP.	—

Countries

Netherlands

Outcome results