alterations of microcirculation chronic heart failure weak heart
Conditions
Interventions
5 different areas of the sub-lingual microcirculation will be imaged by use of
Sidestream Dark Field (SDF) imaging hand microscope. Images will be acquired
during: no pacing (if the patient is not p
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Older than 18 years * Chronic heart failure * CRT device implanted * Informed consent is given
Exclusion criteria
Exclusion criteria: * Younger than 18 years * Pacing dependency (no intrinsic rhythm) * Pre-existing renal failure requiring dialysis * Known haemoglobin diseases, such as sickle cell anemia or thallasemia * Known allergy to acetylcholine or its additives * Missing informed consent * Inability to walk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the CRT- and acetylcholine-related effects on the microcirculation as expressed as the change in mean functional capillary density during different pacing settings and pharmacologic vasodilatation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are additional microvascular parameters: red blood cell velocity and microvascular flow index (MFI). Furthermore, the correlation of microcirculatory and systemic hemodynamic parameters will be investigated. | — |
Countries
Netherlands
Outcome results
None listed