Dose response effect of plasma free fatty acid on insulin mediated capillary recruitment, glucose uptake and glycocalyx modulation

Dose response effect of plasma free fatty acid on insulin mediated capillary recruitment, glucose uptake and glycocalyx modulation - Lipotox

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32150

Enrollment

Registered

2008-09-22

Start date

2008-03-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus

Interventions

1. Clamp with FFAs: placebo, postprandial en diabetic levels through Intralipid infusion. 2. Hyperinsulinemic clamp after 4 hours of FFA clamp 3. Capillary volume measurements: infusion of haes 6% ar

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy male age between 18 and 35 years old

Exclusion criteria

Exclusion criteria: diabetes hypertension smoking cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Increase of capillary blood volume by hyperinsulinemia Recruitment of glycocalyx volume Effects of FFA infusion	—

Secondary

Measure	Time frame
Glycocalyx changes (SDF) Glucose uptake Endothelial function Glycocalyx degradation products NO bioavailability	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)