Functional studies in different forms of hyperkinetic movement disorders

Functional studies in different forms of hyperkinetic movement disorders - Functional studies in hyperkinetic movement disorders

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32146

Enrollment

100

Registered

2008-01-14

Start date

2008-01-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Jerky movement disorders motor tics

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Group 1: Psychogenic movement disorders: We will include patients with *clinically established psychogenic movement disorders*, as defined by Hinson and colleagues and Williams and colleagues . This means movements incongruent with organic disease or inconsistent symptoms, in addition to the presence of other false neurological signs or multiple somatisations. Group 2 : Gilles de la Tourette: DSM-IV diagnosis plus jerky movements of limbs. Group 3: MD patients with proven DYT 11 mutation and DYT11 negative MD patients (the latter for EMG-fMRI only). All patients should have jerky movements frequently.

Exclusion criteria

Exclusion criteria: General exclusion criteria are neurological co-morbidity and the use of substance and/or medication that may influence study results. For the fMRI-EMG study extra exclusion criteria apply. Participants should not have metal implants (e.g. pacemaker), nor should they be pregnant. Moreover, participants with claustrofobia are excluded from fMRI investigation.

Design outcomes

Primary

Measure	Time frame
The purpose of this study is to obtain a better understanding of the pathophysiological substrate of jerky movements. We want to identify brain activations and areas involved with EMG-fMRI that differentiate between MD, GTS and psychogenic movement disorders and we want to identify different activation patterns with EEG-EMG analysis techniques. All findings will be analyzed with respect to common psychiatric co-morbidity, as objectified with standardized psychiatric scales. The final goal is to use these functional studies for future clinical practice to discriminate psychogenic and neurological hyperkinetic movement disorders and guide treatment strategy.	—

Measure

Time frame

The purpose of this study is to obtain a better understanding of the pathophysiological substrate of jerky movements. We want to identify brain activations and areas involved with EMG-fMRI that differentiate between MD, GTS and psychogenic movement disorders and we want to identify different activation patterns with EEG-EMG analysis techniques. All findings will be analyzed with respect to common psychiatric co-morbidity, as objectified with standardized psychiatric scales. The final goal is to use these functional studies for future clinical practice to discriminate psychogenic and *neurological* hyperkinetic movement disorders and guide treatment strategy.

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Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results