Complex Regional Pain Syndrome Posttraumatic Dystrophy Reflex Sympathic Dystrophy
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Patients should fulfill the criteria for CRPS I according to the clinical diagnostic criteria of the IASP: o Continuing pain, allodynia or hyperalgesia that is not limited to the territory of a single peripheral nerve and is disproportionate to the inciting event. o Evidence at some time of edema, changes in skin blood flow or abnormal sudomotoric activity in the region of the pain o This diagnosis is excluded by the existence of conditions that would otherwise account for the degree of pain and dysfunction. ;* Patients should fulfill the diagnostic criteria for CRPS I according to Veldman: o Four or five of: * Unexplained diffuse pain * Difference in skin color relative to the other limb * Diffuse edema * Difference in skin temperature relative to the other limb * Limited active range of motion o Occurrence or increase of the above signs and symptoms after use o The above signs and symptoms are present in an area larger than the area of primary injury or operation and include the area distal to the primary injury. ;* Patients should have one affected and one unaffected arm.
Exclusion criteria
Exclusion criteria: * Patients and controls should have no history of any (other) chronic inflammatory diseases. * Patients and controls are excluded when immunosuppressive medication is used. * Patients and controls are excluded when having an infectious disease at the time of the measurements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome are the differences between patients and controls with respect to cytokine profiles, de availability and amount of myeloperoxidase and the total amount of Gc-globulin and 1,25(OH)2vitaminD3. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome is the difference within patients when comparing between the affected and the unaffected arm. Another secondary outcome is the difference within control subjects when comparing between both arms. | — |
Countries
Netherlands
Outcome results
None listed