Hypopituitarism after Severe Traumatic Brain Injury, an observational study

Hypopituitarism after Severe Traumatic Brain Injury, an observational study - -

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32099

Enrollment

Registered

2008-07-09

Start date

2008-10-21

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypopituitarism loss of function of the pituitary gland

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Men and women 18 to 70 years of age TBI (traumatic brain injury) in past GCS is known at admission CT or MRI has been made after admission Informed consent subject

Exclusion criteria

Exclusion criteria: Pregnancy Pre*existing hypopituitarism or risk factors for hypopituitarism Pre*existing neuro*psychological and/or physical deficit which makes taking part in study and following protocol impossible Corticosteroid use Alcohol abuse and/or drug use

Design outcomes

Primary

Measure	Time frame
Primary aims: 1- To investigate the prevalence of hypopituitarism in patients after traumatic brain injury. 2- To investigate the prevalence of osteoporosis in this TBI population.	—

Secondary

Measure	Time frame
Secondary aims: 3- To investigate possible prognostic factors for development of hypopituitarism after severe traumatic brain injury. 4- To compare physical and neuropsychological performance in patients with and without hypopituitarism after severe TBI. 5- To study bone mineral density in patients after severe traumatic brain injury and study separately the bone mineral density in patients with and without hypopituitarism after traumatic brain injury and compare this with the normal population.	—

Measure

Time frame

Secondary aims: 3- To investigate possible prognostic factors for development of hypopituitarism after severe traumatic brain injury. 4- To compare physical and neuropsychological performance in patients with and without hypopituitarism after severe TBI. 5- To study bone mineral density in patients after severe traumatic brain injury and study separately the bone mineral density in patients with and without hypopituitarism after traumatic brain injury and compare this with the normal population.

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Countries

Netherlands

Outcome results