Are aberrant crypt foci putative precursor lesions of colorectal cancer: a pilot study

Are aberrant crypt foci putative precursor lesions of colorectal cancer: a pilot study - Aberrant Crypt Foci (ACF) and Colorectaal Cancer (CRC)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32090

Enrollment

Registered

2008-06-17

Start date

2009-03-20

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Large Bowel Cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: We will enroll patients undergoing colonoscopy for the following indications: - colorectal cancer screening (10) - colorectal cancer surveillance because of increased risk of recurrent (advanced) adenoma (10) - colorectal cancer surveilance in established HNPCC patients (10) - patients with CRC (pre-surgery colonoscopy) (10)

Exclusion criteria

Exclusion criteria: Patients with known or suspected inflammatory bowel disease.

Design outcomes

Primary

Measure	Time frame
the primary endpoint is to determine number and type of ACF in patients without an increased risk of CRC, patients at an increased of recurrent advanced adenoma based on a personal history of adenomas, patients with established CRC and patients with HNPCC.	—

Secondary

Measure	Time frame
The secondary endpoint is to study the activation of the Wnt pathway in ACF and in matched normal mucosa/advanced adenoma/CRC.	—

Countries

Netherlands

Outcome results