Immunological correlates of protection against measles

Immunological correlates of protection against measles - MMR1 study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32077

Enrollment

750

Registered

2008-12-23

Start date

2013-07-15

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immunity measles

Interventions

interventie

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Children aged 4 - 8 years

Exclusion criteria

Exclusion criteria: Children twice vaccinated with MMR vaccination

Design outcomes

Primary

Measure	Time frame
* Identification of serological (measles neutralizing antibodies and IgG) correlates of protection against clinical measles and measles virus infection.	—

Secondary

Measure	Time frame
* To study a measles IgG correlate for protection in oral fluid; * To describe measles compatible symptoms among once vaccinated individuals who seroconvert to measles but do not meet the clinical case definition (attenuated measles); * To assess the attack rate of measles symptoms in the study population. * To assess the degree of underdiagnosis, underreporting and the burden of disease of measles in the study population.	—

Measure

Time frame

* To study a measles IgG correlate for protection in oral fluid; * To describe measles compatible symptoms among once vaccinated individuals who seroconvert to measles but do not meet the clinical case definition (*attenuated measles*); * To assess the attack rate of measles symptoms in the study population. * To assess the degree of underdiagnosis, underreporting and the burden of disease of measles in the study population.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)