ouderdomsziekten en verouderingsproces age-related diseases diseases of the elderly
Conditions
Interventions
56h fasting with and without food stimuli
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Caucasian male volunteers -Age > 18 years and 20 kg/m2 and
Exclusion criteria
Exclusion criteria: -Any significant chronic or hereditary disease (including renal, hepatic or endocrine disease) -Any significant abnormal laboratory results found during the medical screening procedure -Any use of medication (except for NSAID) -Anosmia or any other (acquired) loss of olfaction (ea. rhinitis) -Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months) -Difficulties to insert an intravenous catheter -Smoking -MRI contraindications -Recent blood donation (within the last 3 months) -Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Fasting endocrine and metabolic serum values -Insulin sensitivity measured by oral glucose tolerance test (OGTT) (area under the curve (AUC) of insulin, C-peptide, free fatty acid (FFA) and glucose) -Glucose and FFA oxidation as determined by indirect calorimetry -Hypothalamic response to oral glucose load as measured by fMRI (functional magnetic resonance imaging) -Anthropometric measurements (weight, waist and hip ratio (WHR), blood pressure, bioelectrical impedance analysis (BIA)) | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed