Gene expression in sepsis and sterile sirs in pediatric patients after cardiac surgery

Gene expression in sepsis and sterile sirs in pediatric patients after cardiac surgery - Gene expression in sirs and sepsis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32059

Enrollment

Registered

2009-09-09

Start date

2010-03-01

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

blood stream infection sepsis

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Pediatric patients who need surgery for congenital heartdefects, and will need cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: steroid administration, participation in other crt

Design outcomes

Primary

Measure	Time frame
To differentiate between sepsis and sterile SIRS by means of gene expression.	—

Secondary

Measure	Time frame
Translate the genes that are expressed in sepsis into a protein which may be used as a diagnostic test in the future. To reduce the unnecessary use of antibiotics in patients after cardiac surgery To prohibit the adverse effect of extensive use of antibiotics such as bacterial resistance or developing superinfection as a result of microbiological inbalance. To reduce procedures which are a result of suspecting an infectious cause, such as unnecessarily changing CVC*s	—

Measure

Time frame

Translate the genes that are expressed in sepsis into a protein which may be used as a diagnostic test in the future. To reduce the unnecessary use of antibiotics in patients after cardiac surgery To prohibit the adverse effect of extensive use of antibiotics such as bacterial resistance or developing superinfection as a result of microbiological inbalance. To reduce procedures which are a result of suspecting an infectious cause, such as unnecessarily changing CVC*s

—

Countries

Netherlands

Outcome results