indigestion upper abdominal complaints
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18-65 years old Recurrent bothersome postprandial fullness, early satiation and/or epigastric pain At least 2 days per week for 3 months or more
Exclusion criteria
Exclusion criteria: Esophagitis Barrett's esophagus Peptic ulcer disease Prior gastrointestinal surgery Pregnancy Drug- or alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in mRNA expression between FD patients and healthy volunteers of at least a factor 1.5. | — |
Secondary
| Measure | Time frame |
|---|---|
| Significantly different apoA-IV concentrations in plasma and/or mucosal biopsies of FD patients and healthy volunteers. Significantly different CCK concentrations in plasma and/or mucosal biopsies of FD patients and healthy volunteers. Correlation mRNA expression, apoA-IV and/or CCK concentration with sensitivity to gastric distension and/or gastric emptying rate. | — |
Countries
Netherlands
Outcome results
None listed