diabetes glucose metabolism disorders
Conditions
Interventions
normal sleep vs short sleep (9.45 vs 5 uur)
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Informed consent • HbA1c
Exclusion criteria
Exclusion criteria: • Psychiatric disorders and/or use of antipsychotic or antidepressant drugs at present or in the past • Use of β-blocking agents, aspirin and prokinetic drugs • Sleep disorders and/or use of sleep medication • Renal, hepatic or other endocrine disease • Any significant chronic disease • Any significant abnormal laboratory results found during the medical screening procedure • Pregnancy • Smoking • Difficulties to insert an intravenous catheter • Recent blood donation (within the last 3 months) • Recent participation in other research projects within the last 3 months or participation in 2 or more projects in one year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - EGP determined by 6,6-D2 glucose infusion in the basal state and during a hyperinsulinemic euglycemic clamp. - Whole body glucose disposal determined by 6,6-D2 glucose infusion in the basal state and during a hyperinsulinemic euglycemic clamp. - Glucose and FFA oxidation as determined by indirect calorimetry - TEE determined by an actimeter - Calorie intake determined by diet diaries | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed