chronic obstructive bronchitis ( COPD) emphysema
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age 40-75 years • Age, pack years, FEV1/FVC and FEV1% predicted must fit in one of 2 groups of table 4.3 • Physically and mentally able to undergo the total study protocol • Written informed consent
Exclusion criteria
Exclusion criteria: • Participation in another study • asthma • Alpha-1-antitrypsin deficiency • Selected within the red made gradation of the 1-3 co-morbidity list in the ACE-27 • Active pulmonary infection like tuberculosis, pneumonia, flue, tracheobronchitis • Active extra-pulmonary infection like hepatitis A-C, cystitis, gastro-enteritis etc • Pulmonary diseases like sarcoidosis, IPF, silicosis, hypersensitivity pneumonitis • Life threatening diseases like carcinoma, AIDS (including HIV+), acute leukaemia etc • Medication that may affect the results of the study: NSAID*s, immunosuppressive agents like prednisolon, metotrexate, azathioprine, sintrom tablets
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Smoking history and behaviour, diet and physical activity level assessed by questionnaire 2. Extensive lung function and CT scanning of the lung 3. Candidate genes for muscle dysfunction and CVD risk 4. Body composition 5. Systemic inflammation 6. Risk factors of metabolic syndrome 7. AGES 8. 6 minute walking distance 9. handgrip strength 10. physical activity level by questionnaire 11. Muscle oxidative phenotype, fibre cross-sectional area and molecular signatures obtained in vastus lateralis muscle biopsies before and after incremental cycly ergometry 12. Skeletal muscle function by isokinetic dynamometry 13. Physical activity level and pattern by accelerometry 14. Glucose tolerance test | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed