Is the hypothalamic neural activity disturbed in patients with familial combined hyperlipidemia?

Is the hypothalamic neural activity disturbed in patients with familial combined hyperlipidemia? - FCH and Hypothalamic Neural Activity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31970

Enrollment

Registered

2008-08-18

Start date

2008-07-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

familial combined hyperlipidemia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male patients (index patients in protocol B) with proven FCH (combined hyperlipidemia, premature atherosclerosis, positive family history for dyslipidemia and premature mortality (before age of 55 yrs)) Age 18-60 yr

Exclusion criteria

Exclusion criteria: BMI > 25 kg/m2 or BMI 2E/day Smoking Presence of active disease or past disease (that may affect variables measured in this protocol) Irregular diet habits Slimming or having a diet on medical indication Medication (including those with central activity, e.g. antidepressants) Claustrophobia Diabetes or a family history positive for diabetes Metal implants or metal objects that cannot be removed (e.g. piercings)

Design outcomes

Primary

Measure	Time frame
1. differences in hypothalamic neural activity (and suppressive effect after oral glucose load) between patients with FCH and healthy volunteers	—

Secondary

Measure	Time frame
mean change (in %) in beat-to-beat variation (lead III heart rhythm recording) during study protocol	—

Countries

Netherlands

Outcome results