Role of dopamine in flexible behaviour

Role of dopamine in flexible behaviour - Dopamine and brain function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31967

Enrollment

192

Registered

2008-08-07

Start date

2008-12-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitieve inflexibiliteit mentale rigiditeit

Interventions

Subjects will be administered the following oral capsules for intake, each on a different visit: 1.25mg bromocriptine, 400mg sulpiride, 100mg levodopa + 25mg carbidopa and placebo.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers between 18 and 45 years of age Right-handed

Exclusion criteria

Exclusion criteria: Metal objects in or around the body Claustrophobia (History of) psychiatric, neurological, endocrine disease or treatment (History of) heart-related disease Regular intake of drugs of abuse

Design outcomes

Primary

Measure	Time frame
• Functional Magnetic Resonance Imaging (fMRI) • Behavioral performance on computerized tasks • Blood plasma levels of prolactin and drug • Self-report questionnaires • Psychophysiological recordings (electrodermal activity, blood pressure, heart rate)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)