Respiratory infections in asthma: the role of host defense against infections, allergic inflammation and vitamin D

Respiratory infections in asthma: the role of host defense against infections, allergic inflammation and vitamin D - asthma and vitamin D

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31956

Enrollment

Registered

2008-08-07

Start date

2008-04-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma

Interventions

The subjects will receive 2 microgram 1,25 (OH) vitamin D (calcitriol) or placebo once daily during seven days (unless discontinued based on assessment on day 4). The wash out time between the inter

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Age 18-45 yrs -BMI12 months) -FEV1>70 % of predicted -Hyperresponsive in standard methacholine challenge (PC20methacholine 3 mm) response to skin prick test (SPT) with 10 common airborne allergen extracts (HAL)

Exclusion criteria

Exclusion criteria: -Age 45 yrs -BMI> 27 -Smoking or ex-smoking (for less than 12 months > 5 pack years) -Usage of inhaled or nasal corticosteroids within last 4 weeks or oral corticosteroids within 3 months prior to and during the study -Usage of vitamin D supplements -Pragnancy

Design outcomes

Primary

Measure	Time frame
- antimicrobial peptides in nasal secretions and sputum - 1,25 (OH) vitamin D in serum - mediators of allergic inflammation in nasal secretions and sputum	—

Secondary

Measure	Time frame
- sputum cell differentials - bacterial and viral load - 25 (OH) vitamin D in serum - exhaled NO-measurements - PTH levels	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)