CANS CRPS CTD RSI WRUED
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For selection of CRPS-1 subjects we will use the Modified research diagnostic criteria for CPRS-1 (Bruehl, 1999). For selection of chronic RSI subjects we will use exclusion criteria specified in the Satsa report (Sluiter, 2001). These criteria are described in Appendix 1 of the protocol. Further inclusion criteria are: • Minimal duration of complaints of 1 year • Complaints are unilateral and restricted to the upper extremity (including shoulder) • Most recent complaints not longer then two weeks ago • McGill questionnaire score over 25 • No contra indication for performing an fmri-scan (see checklist appendix 4)
Exclusion criteria
Exclusion criteria: CPRS: Other musculoskeletal of neurological disorders RSI: only subjects with a-specific RSI will be selected, to this end we will exclude all subjects with specific forms of RSI according to criteria of Sluiter (Saltsa report, 2001) general: The subject does not agree to be informed about unexpected findings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| With fMRI the blood oxygen level dependent (BOLD) response is measured. This response represents neuronal activation. When activity during rest is compared with activation during task performance, the specific areas involved in task performance can be identified. This way we will look at individual data but also at data from the three groups as a whole. Data from control subjects will be compared to affected hand and un-affected hand from the patients. Neuronal activation will be interpreted by looking at the size of the activation area, the contrast in activation between task and rest and the location of the activation. fMRI measurements will be performed using a 1.5 T MRI scanner at the Radiology department. The subjects will be lying on their back with the head inside the scanner for a period of 40-50 minutes. During this period the subject is required to lie still. Via an intercom system the subject can communicate with the researchers. | — |
Secondary
| Measure | Time frame |
|---|---|
| The data will be analyzed and linked to the questionnaires, like the SCL90 (fear and depression), kinesiophobia (TAMPA) and the McGill pain questionnaire. Correlations between the severity and location of complaints, the level of kinesiophobia, en the magnitude of plastic changes in cognitive and emotional areas will be calculated. The following data will be acquired in a Case Record Form: • Demografic data • Weight, height • SCL90 • Pain Catastrophizing • Tampa • Pain anamnesis (see also appendix 2) • Sensibele, autonomous en motor disorders • Localization of pain according to patient • Classification: neuropathic pain, non-neuropathic pain or combination of both (*mixed pain*) • Duration and intensity of pain (VAS-pain en McGill Pain Questionnaire) • Assessment of origin based on medical file (if available) • Inventory of used medication from medical file | — |
Countries
Netherlands
Outcome results
None listed