A pilot study to characterize the effects of ageing on the innate immune response against influenza

A pilot study to characterize the effects of ageing on the innate immune response against influenza - Ageing and the innate immune response against influenza

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31944

Enrollment

Registered

2008-06-24

Start date

2008-09-30

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

flu Influenza

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Subjects have to fulfil all the following criteria: - 20-40 years or >= 65 years old - vaccinated with most recent seasonal influenza vaccine - having a signed informed consent form

Exclusion criteria

Exclusion criteria: The exclusion criteria are: - immune deficiencies - haematological disorders - bleeding disorders - usage of anticoagulants, corticosteroids, NSAIDs and/or statins - diabetes mellitus

Design outcomes

Primary

Measure	Time frame
To determine functional immune responses, after in vitro influenza infection of dendritic cells isolated from young adults and elderly people. The responses will be characterized based on; influenza-specific mRNA expressiom, maturation molecule expression, inhibitory molecule expression, cytokine production and T cell stimulating capacity.	—

Secondary

Measure	Time frame
To determine the variation of the assays for qualifying the innate immune response of DC isolated from young adults or elderly individuals.	—

Countries

Netherlands

Outcome results