psychotrauma traumatic stress
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - PTSD diagnosed by DSM-IV criteria, and confirmed by a diagnostic interview (SCID) (only for patients) - CAPS score > 50 (only for patients) - Male - Age between 18 and 60 years - Exposure to deployment based traumatic stress
Exclusion criteria
Exclusion criteria: - Antidepressant usage within 2 months prior to the start of the study - Usage of any other psychotropic medication within 4 weeks prior to the start of the study - History of psychiatric disease (controls), neurological illness (all subjects), of systemic disease (all subjects) - Sleep disturbed breathing or periodic limb movement disorder - History of alcohol and/or drug abuse (DSM-IV criteria) within 6 months prior to the study - Metal objects in or around the body (braces, pacemaker, etc)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activation of hippocampus and prefrontal cortex during sleep spindles in PTSD subjects as compared with healthy veterans. | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation between delayed recall of the 15 word test and activation of hippocampus and prefrontal cortex during sleep spindles. | — |
Countries
Netherlands
Outcome results
None listed