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Glucotoxity and Endothelial Function

Glucotoxity and Endothelial Function - Glucotoxity and Endothelial Function

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON31935
Enrollment
20
Registered
2008-07-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus

Interventions

None listed

Sponsors

Erasmus MC, Universitair Medisch Centrum Rotterdam
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male or female type 2 diabetic patients; Documented GlycoHb > 8.5% for at least 6 weeks; Age 30-60 years; BMI 25-35 kg/m2; LDL-cholesterol concentration

Exclusion criteria

Exclusion criteria: (Clinical or laboratory) evidence of atherosclerosis or cardiovascular disease; Other systemic disorder with likelihood of (micro)vascular involvement; diabetic nephropathy (albuminuria > 300 mg per day); Kidney disease other than diabetes (serum creatinine > 120 µmol/l); Alcohol abuse; Unwillingness to give written informed consent; Condition that precludes follow-up; Oral anticoagulant therapy or bleeding diathesis

Design outcomes

Primary

MeasureTime frame
To assess the relationship between glycemic control and endothelial function on the microvascular level in diabetes mellitus type 2 (NO, ET-1, Ang II).—

Secondary

MeasureTime frame
To assess underlying mechanisms involved in microvascular endothelial dysfunction and possibly its improvement—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)