Saliva and serum concentrations of fluconazole in children

Saliva and serum concentrations of fluconazole in children - Saliva and serum concentrations of fluconazole in children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31910

Enrollment

Registered

2008-12-11

Start date

2008-06-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(invasive) Candida infection yeast infection

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Included are children on oral (with of without enteral tube) or intravenous fluconazole treatment.

Exclusion criteria

Exclusion criteria: Excluded are children from whom it is impossible to get saliva ,or who have, due to their condition, such a serious mucositis of their oral cavity that saliva is mixed with blood, are excluded.

Design outcomes

Primary

Measure	Time frame
-pharmacokinetics of fluconazole in saliva and serum in children and neonates -fluconazole saliva/serum concentration ratio in children and neonates.	—

Secondary

Measure	Time frame
-Efficacy of fluconazole treatment, as measured by negative (surveillance-)cultures. -Does fluconazole reach sufficient levels in the gastrointestinal tract when the administration route is intravenous	—

Countries

Netherlands

Outcome results