chronic bronchitis COPD emphysema
Conditions
Interventions
None listed
Sponsors
Medisch Centrum Alkmaar
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age above 40 years; • Smoking history >= 10 pack years; • Moderate to very severe COPD (GOLD II to IV); • Currently stable disease (at least 4 weeks after resolution of the last exacerbation); • Willingness to participate in a longitudinal, cohort study; • Willingness of the family physician to have the patient included in a cohort study; • Written informed consent.
Exclusion criteria
Exclusion criteria: • Rapid fatal disease; • Pulmonary condition other than COPD as the main respiratory disease, e.g. bronchiectasis, asthma or pulmonary fibrosis; • Immunosuppression including HIV, organ transplantation or chronic steroid use (more than 10mg prednisolone-equivalent per day); • Patients unable and unwilling to give written informed consent; • Muskulo-skeletal process preventing ambulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Number of exacerbations during two-year follow-up, including exacerbations requiring hospitalization and exacerbations managed by the primary care physicians • Number of deaths of any cause during the two-year follow-up • Number of respiratory-related deaths during the two-year follow-up • Time to next exacerbation, time to next exacerbation requiring hospitalization and time to death during the two-year follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| • Length of stay during hospitalization • Admission and length of stay in intensive care unit • Need for intubation or non-invasive ventilation • Need for oral steroids and antibiotics • Quality of life assessed by Saint Georges Respiratory Questionnaire and SF-36 • Dyspnoea and respiratory symptoms as assessed by the MMRC and LRTI-VAS • Lung function and 6-minute walk test changes | — |
Countries
Netherlands
Outcome results
None listed