cancer of the large bowel colorectal cancer
Conditions
Interventions
None listed
Sponsors
Academisch Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects who will undergo a colonoscopy. 1) average-risk population Employees (50-65 years of age) from companies participating in the ongoing workplace-based CRC screening project by colonoscopy have already been included. 2) high-risk population Patients with a positive family history of CRC visiting the *outpatient clinic for hereditary colorectal cancer* or visiting the endoscopy unit of the MUMC+ for surveillance colonoscopy will be asked to participate into the study. This population will include patients with hereditary forms of CRC (Lynch syndrome or FAP) as well as patients fulfilling the criteria for familial CRC syndrome: i) ³ 1 first degree relative (FDR) with CRC diagnosed
Exclusion criteria
Exclusion criteria: Individuals will be excluded if: -younger than 18 years old -diagnosed with inflammatory bowel disease (Crohn*s disease or ulcerative colitis) -diagnosed with major co-morbidity which may interfere with the outcome of the study (e.g. severe cardiovascular or pulmonary disease, other malignancies)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Test characteristics (sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy) of different molecular and protein markers in the detection of colorectal neoplasia in patients with a low-risk or high-risk for CRC. | — |
Secondary
| Measure | Time frame |
|---|---|
| The identification of risk factors for colorectal neoplasia in subjects at low-risk and at high-risk for CRC. Subsequently, a multi-marker approach for risk stratification in these groups of individuals at different risks for CRC will be designed. | — |
Countries
Netherlands
Outcome results
None listed