Insect venom allergy OR Yellow jacket allergy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Severe systemic reaction after a wasp sting (Müller III - IV) -Positive Intracutaneous Skin Test for Wasp Venom (HEIC>= 0.5 at 1 ug) -Specific IgE wasp > 0.7 kU/l -Age between 18-65 years old -Patients shall give a written informed consent
Exclusion criteria
Exclusion criteria: -Atopy (defined as positive Phadiatop) -Severe asthma or emphysema, based on questionnaire; use of inhaled corticosteroids -Symptomatic coronary heart diseases or severe (even under treatment) arterial hypertension -Diseases with a contra-indication for the use of adrenaline -Severe Kidney disease -Treatment with β-blockers or immunosuppressive drugs -Immunotherapy with venom ever or during the last 5 years with inhalant allergens -Pregnancy, lactation or inadequate contraceptive measures -Alcohol or Drug abuse -Lack of co-operation or severe psychological disorders -Systemic mastocytosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detailed analysis and functional characterization of different regulatory T-cell subpopulations induced after VIT. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of serum IgG, IgA and IgE - levels in correlation with IL-10 and TGFβ | — |
Countries
Netherlands
Outcome results
None listed