Novel diagnostic strategies in children with sickle cell disease: detecting pulmonary hypertension; a pilot study

Novel diagnostic strategies in children with sickle cell disease: detecting pulmonary hypertension; a pilot study - Pulmonary hypertension and sickle cell disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31852

Enrollment

Registered

2008-11-25

Start date

2009-03-17

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HbSC) HbSS or compound heterozygous sickle cell disease (HbSbetathal sickle cell disease

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Sickle cell patient, 12 to 18 years of age.

Exclusion criteria

Exclusion criteria: Acutely or critically ill patients, recent bloodtransfusion (

Design outcomes

Primary

Measure	Time frame
Correlations between echocardiographic results (tricuspidalis Regrurgitant Jet Velocity Value; m/s) and FeNO at different expiratory flow velocities will be tested, in order to evaluate the predictive value of exhaled NO in diagnosis of PH.	—

Secondary

Measure	Time frame
Evaluation of possible (genetic) risk factors for pulmonatry hypertension in SCD	—

Countries

Netherlands

Outcome results