Effects of bilateral subthalamic nucleus deep brain stimulation on plasma triglycerides and glucose metabolism in patients with advanced Parkinson*s disease.

Effects of bilateral subthalamic nucleus deep brain stimulation on plasma triglycerides and glucose metabolism in patients with advanced Parkinson*s disease. - Effects of subthalamic nucleus stimulation on metabolism

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31844

Enrollment

Registered

2008-11-12

Start date

2008-11-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lipids and glucose metabolism in patients with Parkinson disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with idiopathic Parkinson's disease, bilateral subthalamic nucleus deep brain stimulation, and a documented effect of bilateral subthalamic nucleus deep brain stimulation on parkinsonism *measured with the Unified Parkinson*s disease Rating Scale (UPDRS) motor section*equal or more than 75% of the difference between the preoperative provoked OFF and ON phases.

Exclusion criteria

Exclusion criteria: Age less than 18 years, other functional stereotactic neurosurgical interventions (e.g. pallidotomy), psychosis, depression, alcoholism, dyslipidemia (primary or secondary form), use of lipid lowering drugs, unstable weight, presence of type II diabetes mellitus, former history of diabetes gravidarum, first line familial preponderance of type II diabetes mellitus, active smoking, renal insufficiency (creatinine > 150 umol/L, creatinine clearance

Design outcomes

Primary

Measure	Time frame
Evaluation of the effect of stimulation on the subthalamic nucleus on plasma triglycerides and glucose metabolism.	—

Countries

Netherlands

Outcome results