The value of diffusion-weighted MR imaging and biomarkers in cerebrospinal fluid in acute spinal cord injury as predictors of outcome.

The value of diffusion-weighted MR imaging and biomarkers in cerebrospinal fluid in acute spinal cord injury as predictors of outcome. - SPinal cord Diagnostic Improvements (SPIDI) study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31829

Enrollment

Registered

2008-05-20

Start date

2008-01-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal cord injury traumatic myelopathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: closed spinal cord injury associated neurologic deficit primarily referred to UMC St. Radboud Glasgow Coma Scale of 15

Exclusion criteria

Exclusion criteria: penetrating spinal cord injury normal neurologic examination ischaemic spinal cord injury traumatic brain injury pre-existent neurological disorder

Design outcomes

Primary

Measure	Time frame
1 Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using MRI 2 Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using DWI 3 The values of Apparent Diffusion Coefficients (ADC) in the lesion and in normal spinal cord in 10-3 mm2/s measured using DWI 4 The concentrations of Neuron Specific Enolase, Glial Fibrillary Acidic Protein, S-100ß, Neurofilament Protein, Tau and Myelin Basic Protein in CSF in patients with SCI. 5 Evaluation of the ASIA classification system and SCIM of all patients at different times	—

Measure

Time frame

1 Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using MRI 2 Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using DWI 3 The values of Apparent Diffusion Coefficients (ADC) in the lesion and in normal spinal cord in 10-3 mm2/s measured using DWI 4 The concentrations of Neuron Specific Enolase, Glial Fibrillary Acidic Protein, S-100ß, Neurofilament Protein, Tau and Myelin Basic Protein in CSF in patients with SCI. 5 Evaluation of the ASIA classification system and SCIM of all patients at different times

—

Secondary

Measure	Time frame
is not applicable	—

Countries

Netherlands

Outcome results