gastro-enteritis
Conditions
Interventions
None listed
Sponsors
Ministerie van Volksgezondheid, Welzijn en Sport (VWS)
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: A person with complaints of diarrhoea and or vomiting, who is being submitted to the hospital
Exclusion criteria
Exclusion criteria: Not having diarrhoea or vomiting complaints, having had diarrhoea or vomiting complaints in the two weeks before the current episode, being younger than 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of gastroenteritis admissions. Incidence of the following pathogens in patients hospitalised because of gastroenteritis: Bacteriology (RT-PCR): Salmonella, Shigella, Campylobacter, Yersinia, shigatoxin producing E. coli (STEC), entero-aggregative E. coli (EAggEC), enteropathogenic E. coli (EPEC) and Clostridium difficile Virology (RT-PCR): rota-, adeno-, astro-, noro- and sapovirus Parasitology (microscopy and ELISA): Cryptosporidium, Giardia and Dientamoeba fragilis. The course of illness per pathogen in patients hospitalised because of gastroenteritis, including complications, chronic complaints and costs. | — |
Secondary
| Measure | Time frame |
|---|---|
| The DNA isolated from feces for detection of the pathogens will be used for determining genetic polymorphisms in these patients groups. This study will test genes involved in the specific immune response, in particular Th 1 genes, genes involved in innate immunity, and genes involved in inflammatory responses. The frequency of these polymorphisms will be compared to the frequencies determined in population controls in earlier studies. Furthermore, patients groups infected with different pathogens will be compared for frequencies of the polymorphisms. | — |
Countries
Netherlands
Outcome results
None listed