Reproductive function, ovarian reserve and risk of premature menopause in Dutch female childhood cancer survivors

Reproductive function, ovarian reserve and risk of premature menopause in Dutch female childhood cancer survivors - n.v.t.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31794

Enrollment

1250

Registered

2007-01-04

Start date

2006-12-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fertility and ovarian reserve

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Female Treated for malignancy or a central nervous system tumour before the age of 18 Treated between 1965 and 2001 5-year survivors At least 18 years at study entry

Exclusion criteria

Exclusion criteria: For questionnaire: - survivors who do not speak or read Dutch - survivors with severe mental sequelae For the clinical part of the study (blood sample and transvaginal ultrasound) - females who have had both ovaries removed - females who are pregnant or lactating at time of study - females who have not had sexual intercourse are excluded from the ultrasound measurement

Design outcomes

Primary

Measure	Time frame
Sexual activity, childwish at time of completion of the questionnaire, mean time to pregnancy, pregnancy resulting in live birth (yes/no), number of pregnancies, duration of pregnancy, risk of specific adverse pregnancy outcomes (miscarriage, stillbirth), birth weight, age at menopause, age at start of different stages of the menopausal transition, risk of menopause before the age of 40, hormonal levels in blood, uterus volume, and the number of antral follicles as assessed by ultrasound.	—

Measure

Time frame

Sexual activity, childwish at time of completion of the questionnaire, mean time to pregnancy, pregnancy resulting in live birth (yes/no), number of pregnancies, duration of pregnancy, risk of specific adverse pregnancy outcomes (miscarriage, stillbirth), birth weight, age at menopause, age at start of different stages of the menopausal transition, risk of menopause before the age of 40, hormonal levels in blood, uterus volume, and the number of antral follicles as assessed by ultrasound.

—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results