cardiac failure congestive heart failure
Conditions
Interventions
None listed
Sponsors
TweeSteden ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: diagnosis ofchronic heart failure with a left ventricular ejection fraction of 40% or less being on optimal medical therapy NYHA functional class III/IV QRS duration of >=120msec In addition, at least one of the following echocardiographic criteria has to be fulfilled: an aortic pre-ejection delay>140msec, an interventricular mechanical delay>40 msec, or delayed activation of the posterolateral left ventricular wall
Exclusion criteria
Exclusion criteria: Inability to read, write or understand Dutch, a history of psychiatric illness other than mood disorders (depression/anxiety), significant cognitive impairments (e.g. dementia) or life-treating co morbidities (e.g. cancer).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary: Microvascular function as measured by blood flow response to endothelium-dependent and endothelium-independent vasoactieve stimuli (acetylcholine, nitroprusside, local heating); health status; cardiac symptoms; health care consumption. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary: Mortality; morbidity (defined as hospitalisation for cardiac reasons). The primary endpoint, health care consumption, and the secondary endpoints, mortality and morbidity, will be assessed at T4 (i.e. 14 months post-CRT), with the information being obtained through the patients* medical records. | — |
Countries
Netherlands
Outcome results
None listed